Human Antibody Reacting with Bence Jones Proteins
نویسندگان
چکیده
The light (L) polypeptide chains of the human T-globulins carry antigenic determinants designated as group 1 or 2 (1-3). Allotypic determinants designated InV have been found in association with the L chains of 3,,-globulin (4). Natural ly occurring human ant ibody directed toward L chain determinants has been described in detail only for the InV antigens (5). The present studies utilize human Bence Jones (B J) proteins which, in their primary structure, appear to be identical with the L chains of the several human ?-globulins but are entirely of either group 1 or 2 antigenic specificity (1). Tannic acid-treated sheep erythrocytes coated with highly purified group 1 or 2 Bence Jones proteins detect naturally occurring human antibody directed toward L chain determinants which appear to be blocked in intact "y-globulins by the heavy (H) polypeptide chains.
منابع مشابه
Naturally Occurring Human Antibody Reacting with Bence Jones Proteins
Agglutinating substances having characteristics of naturally occurring macroglobulin antibodies to human Bence Jones proteins have been identified in human sera. By means of hemagglutination and hemagglutination inhibition techniques, common determinants have been demonstrated on the light (L) polypeptide chains of pooled normal human gamma(2)-globulin and on some Bence Jones proteins of group ...
متن کاملStructural Features of Human Light Chains
By Alan Solomon W ITHIN the past decade, studies by molecular geneticists on the composition and organization of immunoglobulin (Ig)-coding genes at the DNA level have vastly increased our understanding of the genetic mechanisms responsible for generating antibody diversity and for linking Ig synthesis to cellular differentiation. This new information, which has far-reaching biological and clin...
متن کاملLight chains of immunoglobulins: structural-genetic correlates.
By Alan Solomon W ITHIN the past decade, studies by molecular geneticists on the composition and organization of immunoglobulin (Ig)-coding genes at the DNA level have vastly increased our understanding of the genetic mechanisms responsible for generating antibody diversity and for linking Ig synthesis to cellular differentiation. This new information, which has far-reaching biological and clin...
متن کاملAlan Solomon and Carla
The immunochemical demonstration that the Bence Jones protein from the urine of an individual patient with multiple myeloma was antigenically identical to a portion of the homologous serum myeloma protein (1), and the establishment of the chemical and structural similarities between Benee Jones proteins and light polypeptide chains (2, 3) which are common to immunoglobulins of all known classes...
متن کاملBence Jones proteins bind to a common peptide segment of Tamm-Horsfall glycoprotein to promote heterotypic aggregation.
Bence Jones proteins (BJPs) are the major pathogenic factor causing cast nephropathy ("myeloma kidney") by coaggregation with Tamm-Horsfall glycoprotein (THP). Understanding the interaction between these proteins is therefore important in developing treatment strategies to prevent renal failure from cast formation in multiple myeloma. We developed an enzyme-linked immunoassay to examine this ph...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003